Diseases treated by cord blood stem cell transplantation

 

The most frequent use of stem cell transplantation from a matching donor is the treatment of patients suffering from leukaemia and other malignant diseases of the circulatory system, and patients with hereditary disorders of the immune system, metabolism and haemoglobin synthesis (severe anaemias).

Malignant diseases: acute lymphoblastic leukaemia, acute myeloid leukaemia, chronic myeloid leukaemia, myelodysplastic syndrome, neuroblastoma.

Non-malignant diseases: adrenoleukodystrophy, amegakaryocytic thrombocytopenia, Blackfan-Diamond syndrome, congenital dyskeratosis, Fanconi anaemia, Gunther’s disease, Hunter syndrome, Hurler syndrome, severe aplastic anaemia, Kostmann syndrome, Lesch-Nyhan syndrome, osteopetrosis, severe combined immunodeficiency, thalassaemia, X-linked lymphoproliferatives.

Pročitaj više..

Advantages and disadvantages of haematopoietic stem cells from cord blood

 

What are the advantages of haematopoietic stem cells from cord blood?

  • The number of potential donors is, in theory, unlimited, as blood can be procured after every delivery.
  • The process of graft selection and administration is quick, which makes it possible to timely treat the patient.
  • The quantity of tissue rejection after the transplantation of a HSC graft from cord blood is smaller due to a weaker immunological reaction.

 

What are the disadvantages of haematopoietic stem cells from cord blood?

  • A limited number of cells, which directly depends on the quantity of procured cord blood; it is usually enough for transplantation to a child...

    Pročitaj više..

The difference between cord blood stem cells and other stem cells

 

The youngest cells are embryonic stem cells, which can generate any type of cell in our bodies. They can only be procured from the foetus and are not applied in therapy due to ethical disputes.

Adult stem cells are found in tissues of children and adults and have already been channeled towards generating a specific type of tissue. The most accessible adult stem cells are haematopoietic stem cells from bone marrow or peripheral blood, for example, bone marrow and peripheral blood stem cells.

Haematopoietic stem cells from cord blood circulate in foetal blood. They are a younger form of those found...

Pročitaj više..

What are stem cells and what are they for?

 

A stem cell of any tissue is the cell that can generate all the cells of the tissue. The most famous and most accessible is the haematopoietic stem cell (HSC), which renews haematopoietic tissue. It generates red blood cells, cells which transfer oxygen; leukocytes, cells which defend the body; and platelets, cells which prevent haemorrhaging. There are three sources of stem cells in the human body: bone marrow, peripheral blood and umbilical cord blood. Haematopoietic stem cells are used in treating haematological diseases, such as leukaemias and lymphomas, serious bone marrow failures (aplastic anaemia) and serious failures of the...

Pročitaj više..