Advantages and disadvantages of haematopoietic stem cells from cord blood
What are the advantages of haematopoietic stem cells from cord blood?
- The number of potential donors is, in theory, unlimited, as blood can be procured after every delivery.
- The process of graft selection and administration is quick, which makes it possible to timely treat the patient.
- The quantity of tissue rejection after the transplantation of a HSC graft from cord blood is smaller due to a weaker immunological reaction.
What are the disadvantages of haematopoietic stem cells from cord blood?
- A limited number of cells, which directly depends on the quantity of procured cord blood; it is usually enough for transplantation to a child and persons with smaller body weight. The success of the transplantation is affected by, among other things, the number of transplanted cells, so adults can receive two cord blood grafts.
- The recovery of the haematopoietic system after transplantation is slower, because the transplanted cells are less mature.